Show metadata Hide metadata

(19)

(11)

2 271 357

(13)

(51)

IPC

C07D323/02(2006-01-01)

A61K31/335(2006-01-01)

A61P33/06(2006-01-01)

(21) (22)

Application

2004101409/04, 2002-06-21

(24)

Start date

2002-06-21

(22)

Actual filing date

2002-06-21

(45)

Published

2006-03-10

(72)

Inventor

Vennerstrom Dzhonatan L.Sholle ZhakDun JujsjanMatil' JugPadmanilajam ManijanTan Juan'TsinCharman Uil'Jam N.

(73)

Holder

Medsinz For Malehrija Vencher

SPIRO- OR DISPIRO-1,2,4-TRIOXOLANE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT Russian patent published in 2006 - IPC C07D323/02 A61K31/335 A61P33/06

Abstract RU 2271357 C2

FIELD: organic chemistry, medicine, parasitology, pharmacy.

SUBSTANCE: invention relates to spiro- or dispiro-1,2,4-trioxolane of the general formula (I): wherein R₁ and R₂ taken in common represent spiroadamantyl, 3,3,5,5-tetramethylspirocyclohexyl, spirocyclododecanyl; R₃ and R₄ are similar or different and taken among substituted or unsubstituted aromatic or pyridyl group wherein neither among R₃and R₄ can't represent hydrogen atom; also, R₃ and R₄ taken in common can form substituted or unsubstituted alicyclic group that is broken optionally with one oxygen, sulfur or nitrogen atom. Proposed compounds can be easily used for synthesis of nontoxic and active agents used against anti-malaria parasites. Also, invention describes a pharmaceutical composition based on compounds of the formula (I) and a method for treatment of malaria and schistosomiasis.

EFFECT: improved method for treatment, valuable medicinal properties of compounds and composition.

19 cl, 10 tbl, 9 ex

Similar patents RU2271357C2

Title	Year	Author	Number
DISPIRO 1,2,4-TRIOXOLANES AS ANTI-MALARIA AGENTS	2008	Vennerstrom Dzhonatan L. Don Jujsjan Charman S'Juzan A. Uitlin Serdzhio Sholle Zhak Krik Darren Dzh. Van Sjaofan Sriragkhavan Kamaradzh Chzhou Lin' Matil' Jug Charman Uil'Jam N.	RU2493159C2
DERIVATIVES OF CYCLOPROPYL-β-AMINO ACID	2004	Shvarts Dzhejkob Brehdli Vustrou Dehvid Jurgen	RU2312853C2
RETINOID DERIVATIVES WITH ANTITUMOR ACTIVITY	2017	Pisano, Claudio Dallavalle, Sabrina Cincinelli, Raffaella Merlini, Lucio	RU2748838C2
USE OF PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTION	2015	Bravo-Altamirano Karla Dekorver Kyle A. Jones David M. Daeuble Sr. John F. Herrick Jessica Epp Jeffrey B. Delorbe Johnathan E. Meyer Kevin G. Yao Chenglin	RU2704867C2
PESTICIDE COMPOSITIONS AND RELATED METHODS	2013	Borromeo, Peter Deamicis, Carl Ross, Ronald Wessels, Frank Leplae, Paul Renee Garizi, Negar Patny, Akshay Knueppel, Daniel Lowe, Christian T. Trullinger, Tony K. Hunter, Ricky Kubota, Asako Walsh, Martin J, Zhang, Yu Demeter, David A. Niyaz, Noormohamed M. Buysse, Ann M.	RU2651369C1
FIVE-MEMBERED RINGS-CONTAINING SPIROCOMPOUNDS, PHARMACEUTICAL COMPOSITION	1994	Fisher Abrakham Karton Jishal Marsiano Daniehl' Barak Dov Meshulam Khajm	RU2129555C1
TREATMENT OF HELICOBACTER PYLORI INFECTIONS WITH USE OF MTAN INHIBITORS	2015	Schramm, Vern, L. Clinch, Keith Gulab, Shivali, Ashwin	RU2663803C2
HYDROXYPURINE COMPOUNDS AND WAYS OF THEIR USE	2015	U Linyun Lun Chaofen Chzhan Pen Chen Syaosin Chzhan Li Lyu Chzhovej Li Tszyan Chen Shukhuej	RU2673458C1
NEW 1,2,4-TRIAZOLO-[3,4-B]-1,3,4-THIADIAZOLE DERIVATIVES	2017	Trafalis, Dimitrios	RU2765180C2
METHODS FOR PREPARING SUBSTITUTED ARYL-CONDENSED AZAPOLYCYCLIC COMPOUNDS, INTERMEDIATE SUBSTANCES AND METHODS FOR THEIR PREPARING	2002	Singer Robert Alan Makkinli Dzhejson Dehniel	RU2282619C9

RU 2 271 357 C2

Authors

Vennerstrom Dzhonatan L.

Sholle Zhak

Dun Jujsjan

Matil' Jug

Padmanilajam Manijan

Tan Juan'Tsin

Charman Uil'Jam N.

Dates

2006-03-10—Published

2002-06-21—Filed