PYRANOINDAZOLES, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND THEIR USING IN GLAUCOMA TREATMENT Russian patent published in 2006 - IPC C07D491/52 A61K31/4162 A61P27/06

Abstract RU 2273641 C2

FIELD: organic chemistry, medicine, ophthalmology, pharmacy.

SUBSTANCE: invention relates to new pyranoindazoles of the formula (1): wherein R¹ and R² are chosen independently from hydrogen atom or alkyl group; R³and R⁴ represent independently hydrogen atom or alkyl group; R⁵, R⁶ and R⁷ mean hydrogen atom; R⁸ and R⁹ mean hydrogen atom, hydroxyl, alkoxy-group, -NR¹⁰R¹¹, -OC(=O)NR¹R², -OC(=O)-(C₁-C₄)-alkyl or alkylthiol; R¹⁰ and R¹¹ mean hydrogen atom; A means -(CH₂)_n, C=O; B means a simple or double bond; n = 0-2; Y means nitrogen atom (N); X means carbon atom C; dotted line means the corresponding simple or double bond. Also, invention relates to a pharmaceutical composition based on compounds of the formula (1), to a method for regulating normal or enhanced intraocular pressure, method for treatment of glaucoma and method for blocking or binding serotonine receptors. Invention provides preparing new pyranoindazoles possessing the valuable pharmaceutical effect.

EFFECT: valuable medicinal properties of compounds and composition.

14 cl, 4 tbl, 22 ex

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RU 2 273 641 C2

Authors

Chehn' Khvan-Khsin

Mehj Dzhess A.

Severns Brion S.

Dates

2006-04-10—Published

2002-05-30—Filed