FIELD: pharmacology.
SUBSTANCE: document describes methods of using compounds of formula (I) to modulate PKM2 activity in a subject. The invention relates to the field of pharmacology and medicine and is aimed at modulating the activity of M2-pyruvate kinase (PKM2). The use of a compound selected from the group or a pharmaceutically acceptable salt of any of the above compounds for the treatment of diseases associated with abnormal PKM2 activity is disclosed, the disease being selected from the group consisting of cancer, obesity, diabetes-related disease, atherosclerosis, coronary artery disease (CAD), Bloom's syndrome (BS), or an autoimmune disease.
EFFECT: invention provides effective treatment of diseases associated with PKM2 activity.
20 cl, 14 dwg, 29 tbl, 11 ex
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Authors
Dates
2023-06-06—Published
2018-08-15—Filed