RETINOID COMPOUNDS, METHOD FOR THEIR PREPARING (VARIANTS), PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT OF RESPIRATORY WAY OBSTRUCTIVE DISEASE, CANCER OR DERMATOLOGICAL DISTURBANCE OF DISORDER Russian patent published in 2006 - IPC C07D311/58 C07D335/06 C07D215/12 C07D409/12 A61K31/38 A61P17/00 

FIELD: organic chemistry, heterocyclic compounds, medicine, pharmacy.

SUBSTANCE: invention relates to new biologically active heterocyclic retinoid compounds. Invention describes retinoid compounds corresponding to the formula (I): or their pharmaceutically acceptable salts, solvates or hydrates wherein n means a whole number from 0 to 2; A represents optionally substituted phenyl; B represents oxygen (O), sulfur (S) atom or -NR⁶ wherein R⁶ represents hydrogen atom or alkyl; Y represents -OR⁷ wherein R⁷ represents hydrogen atom, alkyl, optionally substituted phenyl, aralkyl wherein aryl fragment means optionally substituted phenyl, cycloalkyl or cycloalkylalkyl; Z represents -C(R¹⁰¹)₂-, -R¹⁰²C=CR¹⁰²-, -C≡C-, -C(R¹⁰³)₂S-, -C(O)O- or -C(O)NR¹⁰- wherein each among R¹⁰, R¹⁰¹, R¹⁰² and R¹⁰³ represents independently hydrogen atom or alkyl; R¹ and R² represent independently hydrogen atom or alkyl; R³ represents hydrogen atom or alkyl; R⁴ and R⁵ represent independently hydrogen atom, (C₁-C₈)-alkyl or arylalkyl wherein aryl fragment means optionally substituted phenyl. Also, invention describes methods for preparing retinoid compounds, a pharmaceutical composition based on thereof and a method for treatment and/or prophylaxis of respiratory ways obstructive disease, cancer or dermatological disturbance or disorder. Invention provides preparing new compounds possessing useful biological properties.

EFFECT: improved treatment method, valuable medicinal properties of compounds and composition.

28 cl, 10 tbl, 16 ex