FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to new derivatives of diarylic acid of the formula (Ia): 
wherein 
represents quinolinyl or oxazolyl substituted with phenyl and optionally substituted with halogen atom wherein indicated phenyl can be substituted with alkoxy-group or halogen atom; a = 1; b = 0 or 1; R1, R2, R3 and R4 represent hydrogen atom; A represents compound of the formula: 
R5, R6, R7, R8, R15 and R16 represent hydrogen atom; c = 0; d = 0' g means a whole number from 1 to 5; B and E represent a chemical bond; Z represents HOOC-; R' and R'' are ring substitutes, more preferably, R' means hydrogen atom, alkoxy-, benzyloxy-, aryloxy-group or phenyl substituted with alkyl; R'' means lower alkyl or alkoxy-group, and to their pharmaceutically acceptable salts. Also, invention relates to pharmaceutical composition possessing activity of agonist or antagonist of PPAR receptor based on these compounds. Invention provides preparing new compounds of the formula (Ia) and pharmaceutical composition based on thereof that can be used in treatment of diseases that can be modulated by using the claimed compounds possessing binding activity of PPAR ligand.
EFFECT: valuable medicinal properties of compounds.
6 cl, 7 tbl, 109 ex
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