FIELD: chemistry.
SUBSTANCE: invention relates to a new tetrahydroquinoline derivative of formula
or its pharmaceutically acceptable salt, wherein R1: hydrogen, lower alkyl, halogen or carboxy; R2: hydrogen, lower alkyl, halo-lower alkyl, halogen, cyano, or carboxy; R3 and R4: lower alkyl; R5 and R6 are selected from hydrogen, carboxy-lower alkylamino, carboxycyclopropylamino, lower alkylsulfonylamino, phenylsulfonylamino, halophenylsulfonylamino, lower alkylphenylsulfonylamino, halophenylkarbonilamino, piridinilsulfonilamino, lower alkylaminosulfonyl and halophenylaminosulfonyl; with the provision that both R5 and R6 do not simultaneously represent hydrogen; R7: hydrogen or lower alkyl. The invention also relates to the pharmaceutical composition based on the compound of the formula (I) and to the application of the compound of the formula (I).
EFFECT: invention provides obtaining new tetrahydroquinoline derivatives useful as an activator of AMP-activated protein kinase (AMPK).
20 cl, 1 tbl, 94 ex
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