OLIGOSACCHARIDE-CONTAINING 14-AMINOSTEROIDS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT, METHOD OF AMINO-GROUP INCORPORATION Russian patent published in 2000 - IPC

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention describes the novel oligosaccharide-containing 14-aminosteroids of the general formula (I) where R₁ means COO-R₅ where R₅ is lower alkyl with 1-6 carbon atoms, COR where R is amino-group possibly substituted with lower alkyl with 1-6 carbon atoms; R₂ is NH₂-group; R₃ is oligosaccharide residue of the formula (II) where R_g means hydrogen atom, hydroxy-, acetoxy-, benzoylhydroxy-group; R₁₀ means oxygen atom and if further R₁₁ is a substituent of terminal monosaccharide residue then R₁₁ means OH, methyl, acetoxy-group and R₁₂ means hydrogen atom, methyl, methylhydroxymethyl or oligosaccharide residue of the general formula (III) where R₁₄ and R₁₅ are similar or different and mean lower alkyl with 1-6 carbon atoms; R_17/ can be hydrogen atom, hydroxy-, acetoxy- or benzoxy-group; R₁₈ and R₁₉ means hydroxy-, acetoxy- or benzoxy-group or oligo-saccharide residue of the general formula (IV) where R₁₄ and R₁₅ are similar or different and mean lower alkyl with 1-6 carbon atoms; R_14a means hydroxy-, acetoxy-group; R₄ means H. Compounds of the formula (I) show activity in treatment of patients with congestive heart failure since they enhance contractive capability of heart muscle. Invention describes also method of their synthesis, pharmaceutical composition based on compounds of the formula (I), method of patient treatment and method of incorporation of amino-group. EFFECT: new compounds indicated above, improved method of synthesis, valuable pharmacological properties. 12 cl, 7 ex