DERIVATIVES OF N-HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT Russian patent published in 2006 - IPC C07D405/14 C07D403/04 A61K31/506 A61P19/02 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention describes derivatives of N-heterocyclic compounds of the formula: , wherein n and m mean independently a whole number from 1 to 4; A means -C(O)OR¹ or -C(O)N(R¹)R²; W means -CH; R¹ means hydrogen atom or (C₁-C₈)-alkyl; R means hydrogen atom, (C₁-C₈)-alkyl, heterocyclyl-(C₁-C₄)-alkyl chosen from the group comprising benzodioxolyl-, benzodioxanyl- or dihydrobenzofuranylalkyl or phenyl-(C₁-C₄)-alkyl substituted possibly with alkoxy-group; R⁴ means cyano-group or heterocyclyl chosen from the group comprising pyridinyl, morpholinyl, benzodioxolyl or benzodioxanyl-radical if m = 1; if m means from 2 to 4 then R⁴ can mean additionally hydroxy-group, -NR¹R² wherein R¹ and R² mean independently hydrogen atom, (C₁-C₈)-alkyl or benzyl-radical, -N(R¹)-C(O)-R¹, -N(R¹)-C(O)-OR¹, -N(R¹)-S(O)_t-R¹ wherein R¹ means hydrogen atom or (C₁-C₈)-alkyl, -N(R¹)-C(O)-N(R¹)₂ wherein R¹ means hydrogen atom; R⁵ means (C₁-C₈)-alkyl; t = 2, and their stereoisomers and pharmaceutically acceptable salts, pharmaceutical composition based on thereof and a method for treatment of diseases, in particular, rheumatic arthritis.

EFFECT: valuable medicinal properties of compounds and composition.

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