FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to compound of the formula (I): 
or its pharmaceutically acceptable salt, solvate or hydrolyzed ester wherein R1 and R2 represent independently hydrogen atom or (C1-C3)-alkyl; X represents oxygen atom (O); one of radicals R3 and R4 represents independently hydrogen atom and another represents (C1-C3)-alkyl; X1 represents -CH2 or -SO2; R5 represents (C1-C6)-alkyl (possibly substituted with (C1-C6)-alkoxy- or (C1-C6)-alkylthio-group), (C2-C6)-alkenyl, (C0-C6)-alkylphenyl (wherein phenyl is substituted possibly with one or more -CF3 group, halogen atom, (C1-C3)-alkyl, (C1-C3)-alkoxy-group), -CO-(C1-C6)-alkyl, -SO2-(C1-C6)-alkyl; R6 represents phenyl or 6-membered heteroaryl group comprising 1 or 2 nitrogen atom (N) and wherein phenyl or heteroaryl group are substituted possibly with 1, 2 or 3 groups chosen from group consisting of (C1-C6)-alkyl, phenyl (possibly substituted with one or more group chosen from halogen atom, -CF3, (C1-C3)-alkyl, O-(C1-C3)-alkyl, -CN). Compound of the formula (I) is designated for using as activator of human receptors activated by peroxisomal proliferators (hPPAR). Invention provides derivatives of propionic acids activating human receptors activated by peroxisomal proliferators (hPPAR).
EFFECT: valuable medicinal properties of derivatives.
14 cl, 58 ex
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