NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS, PHARMACEUTICAL COMPOSITION COMPRISING THEREOF, THEIR USING IN PREPARING MEDICINAL AGENT FOR TREATMENT OF HIV-1, INTERMEDIATE COMPOUNDS FOR THEIR PREPARING Russian patent published in 2006 - IPC C07D405/12 C07D409/12 C07D413/12 C07D417/12 C07D311/94 C07C43/23 A61K31/4402 A61K31/35 A61K31/381 A61P31/18 

FIELD: organic chemistry, medicine, virology, pharmacy.

SUBSTANCE: invention relates to new non-nucleoside inhibitors of reverse transcriptase activity of the formula (1): wherein R₁ represents oxygen atom (O), sulfur atom (S); R₂ represents optionally substituted nitrogen-containing heterocycle wherein nitrogen atom is at position 2 relatively to the bond with (thio)urea; R₃ represents hydrogen atom (H), (C₁-C₃)-alkyl; R₄-R₇ are chosen independently from hydrogen atom (H), (C₁-C₆)-alkyl, (C₂-C₆)-alkenyl, (C₂-C₆)-alkynyl, halogen-(C₁-C₆)-alkyl, (C₁-C₆)-alcanoyl, halogen-(C₁-C₆)-alcanoyl, (C₁-C₆)-alkoxy-, halogen-(C₁-C₆)-alkoxy-group, hydroxy-(C₁-C)-alkyl, cyano-group, halogen atom, hydroxy-group; X represents group of the formula: -(CHR₈)-D-(CHR₈)_m- wherein D represents -O or -S-; R₈ represents hydrogen atom (H); n and m represent independently 0, 1 or 2, and to its pharmaceutically acceptable salts. Also, invention relates to a pharmaceutical composition based on these compounds possessing inhibitory effect with respect to activity of HIV-1 reverse transcriptase, and to using these compounds in preparing medicinal agents used in treatment of HIV-1 and to intermediates compounds.

EFFECT: valuable medicinal and biochemical properties of compounds and composition.

45 cl, 1 tbl, 57 ex