STRAIN OF HYBRID CULTURING Rattus norvegicus 122H9 CELLS WHICH IS PRODUCER OF CROSS-REACTIVE NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST PATHOGENIC FOR HUMAN ORTHOPOXVIRUSES Russian patent published in 2006 - IPC C12N5/16 C12P21/08 

Abstract RU 2281327 C2

FIELD: biotechnology and virology.

SUBSTANCE: strain of hybrid culturing Rattus norvegicus 122H9 cells is disclosed. Said strain is obtained by fusion of rat myeloma cells 210RC.Y3-Ag1.2.3 with rat spleen cells LOU, immunized with purified ectromelia virus of K-1 strain. Said strain is producer of cross-reactive neutralizing monoclonal antibodies against pathogenic for human orthopoxviruses.

EFFECT: vaccines for prophylaxis and therapy of diseases associated with pathogenic for human orthopoxviruses.

2 tbl, 5 ex

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RU 2 281 327 C2

Authors

Vasil'Eva Marina Aleksandrovna

Belanov Evgenij Fedorovich

Konovalov Evgenij Evgen'Evich

Razumov Ivan Alekseevich

Loktev Valerij Borisovich

Dates

2006-08-10Published

2004-09-01Filed