MEDICINAL FORMULATION POSSESSING ANTIBACTERIAL EFFECT AND METHOD FOR ITS MAKING Russian patent published in 2006 - IPC A61K31/5365 A61K9/22 A61P31/04 

FIELD: medicine, pharmaceutical technology, pharmacy.

SUBSTANCE: invention relates to a medicinal formulation used in treatment of lung, moderate and severe infections of lower respiratory ways, organs of otorhinolaryngology sphere, urinary ways, kidneys, genital organs, skin and soft tissues caused by sensitive strains of microorganisms. The medicinal formulation consists of a core and envelope wherein a core comprises the following components, wt.-%: levofloxacin, 60-69; crospovidone, 2.9-4.5; magnesium stearate, 0.1-1.0; lauryl sulfate sodium, 0.5-2.0; polyvinylpyrrolidone, 2.0-3.5; microcrystalline cellulose, the balance; envelope comprises the following components, wt.-%: yellow iron oxide, 0.05-0.1; red iron oxide, 0.05-0.1; hydroxypropylcellulose, 35.0-42.0; polyethylene glycol, 10.0-20.0; titanium dioxide, 4.8-9.0, and hydroxypropylmethylcellulose, the balance. Also, invention discloses a method for making this medicinal formulation. Invention provides rapid release of active substance in digestive tract and high strength of the proposed medicinal formulation.

EFFECT: improved preparing method, enhanced and valuable medicinal and pharmaceutical properties of formulation.

5 cl, 1 tbl, 3 ex