FIELD: medicine, pharmaceutical industry.
SUBSTANCE: invention relates to production of solid pharmaceutical agents enhancing excretive kidney function useful in treatment of hypertension and chronic heart failure, accompanying with retention of sodium and water in organism. Claimed pelleted pharmaceutical composition comprises core, containing (mass %) inapamide 0.8-1.0; lactobiose 51-30; polyvinylpyrrolidone 1-3; microcrystalline cellulose 20-30; starch glycolate 3-10; magnesium stearate 0.1-1.04 and stomach soluble shell containing (mass %): oxypropylcellulose 25-40; vinylpyrrolidone-vinylacetate copolymer 25-40; titania 20-30; and talc 10-20. Method for production of such composition also is disclosed.
EFFECT: pelleted pharmaceutical composition of high active ingredient solubility without losses of tablet stability.
7 cl, 1 tbl, 3 ex
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