FIELD: pharmaceutical industry, in particular, in particular solid pharmaceutical formulations useful in treatment of arterial hypertension and chronic heart failure.
SUBSTANCE: claimed formulation comprises core containing (mass %): inapamide 0.3-2.0; colloidal silica 0.1-2.5; hydroxypropyl cellulose 8-35; vinyl pyrrolidone-vinyl acetate copolymer 1.8-4.5; magnesium stearate 0.1-1.0; lactose 15.0-55.0; and balance: microcrystalline cellulose; and sell dissolvable in stomach and containing (mass %) polyethylene glycol 10.0-17.0; titanium dioxide 11.5-20.5; talk 1.8-6.3; and balance hydroxypropylmethyl cellulose. Method for production of said formulation also is provided.
EFFECT: Agent with gradual releasing of active ingredient; tablets with increased mechanical strength; preparation of improved quality in storage process.
3 cl, 1 tbl, 2 ex
