MEDICINAL FORMULATION SHOWING ANTI-AGGREGATING EFFECT AND METHOD FOR ITS PREPARING Russian patent published in 2007 - IPC A61K31/4365 A61K9/20 A61P7/02 

FIELD: medicine, pharmacy, pharmaceutical technology.

SUBSTANCE: invention describes a medicinal formulation possessing an anti-aggregating effect. Proposed medicinal formulation consists of a core comprising the following components, wt.-%: clopidogrel hydrosulfate, 44.0-65.0; lactose, 15.0-37.0; starch, 2.4-9.8; microcrystalline cellulose, 2.2-7.0; hydroxypropylmethylcellulose, 0.3-0.8; polyethylene glycol, 1.5-4.0; magnesium stearate, 0.1-1.0, and stearic acid, 0.1-1.0, and envelope comprising the following components, wt.-%: hydroxypropylmethylcellulose, 58.0-72.0; polyethylene glycol, 13.5-20.5; titanium dioxide, 13.5-20.5, and red iron oxide, 0.5-1.0. Also, invention discloses a method for preparing this medicinal formulation. Hydroxypropylmethylcellulose as a component of a core enhances mechanical strength of tablet that provides optimization of the envelope applying process. Additional technological procedure in preparing a mixture of potato starch with polyethylene glycol 6000 Da and part of clopidogrel hydrosulfate allows uniform distribution of components that enhanced bioavailability of the medicinal agent and increased anti-aggregation effect of the preparation being without elevating the therapeutic dose Invention can be used in prophylaxis of ischemic disturbance in patients suffering from atherosclerosis.

EFFECT: improved preparing method, valuable medicinal properties of formulation.

6 cl, 1 tbl, 3 ex