FIELD: medicine, pharmaceutical technology, pharmacy.
SUBSTANCE: invention relates to producing solid combined medicinal formulations of preparations exhibiting an antihypertensive effect, increasing heart blow-out index and enhancing tolerance to physical load in patient with the congestive cardiac insufficiency. The proposed medicinal agent comprises the following components, wt.-%: perindopril erbumine, 0.6-7.0; microcrystalline cellulose, 12.0-35.0; magnesium stearate, 0.3-1.7; aerosil, 0.1-1.0; croscarmelose-sodium, 1.1-7.0, and lactose, the balance. Also, invention discloses a method for preparing the medicinal formulation. Invention reduces loss of perindopril in process for the formulation preparing, retaining the parent properties of perindopril erbumine and enhancing biological availability of agent.
EFFECT: enhanced and valuable properties of agent, improved preparing method.
3 cl, 2 tbl, 2 ex
