DERIVATIVES OF CALOPOROSIDE, METHOD FOR THEIR PREPARING AND THEIR USING Russian patent published in 2006 - IPC C07H13/06 C07H15/18 C12P19/12 A61K31/7016 A61P35/00 

FIELD: organic chemistry, microbiology, medicine, pharmacy.

SUBSTANCE: invention relates to novel derivatives of caloporoside of the formula (I): wherein R₁, R₂ and R₃ mean independently of one another hydrogen atom (H) or acyl residues with 1-10 carbon (C)-atoms; R₄ means hydrogen atom (H) or -C(O)(CH₂)_n-COOH wherein n = 1-7 under condition that not all R₁, R₂, R₃ and R₄ mean hydrogen atom (H), and their physiologically acceptable salts also. Also, invention relates to a method for synthesis of compound of the formula (I) or its physiologically acceptable salts. Method involves fermentation of the strain Gloeoporus dichrous (Fr:Fr) Bres. ST001714, DSM 13784 under aerobic conditions at temperature 18-35°C and pH = 5-8, isolation of one or some derivatives of caloporoside that can be conversed, if necessary, to physiologically acceptable salts, and to using compound of the formula (I) as CDK-inhibitor in treatment of cancer or another diseases associated with pathological damage of cells proliferation, and to a medicinal agent based on thereof and to a method for its preparing.

EFFECT: improved preparing method, valuable medicinal properties of derivatives.

14 cl, 5 tbl, 8 ex