BLOCK-COPOLYMER WITH DECREASED CONTAMINANT CONTENT, POLYMER CARRIER, PHARMACEUTICAL AGENTS ON POLYMER FORM AND METHOD FOR PRODUCTION THEREOF Russian patent published in 2006 - IPC C08G69/40 A61K47/48 A61K31/704 

Abstract RU 2282641 C2

FIELD: polymers, in particular block-copolymer of polyethylene glycol and poly(acidic amino acid) or salt thereof.

SUBSTANCE: claimed block-copolymer is obtained by polyethylene glycol purification using ion exchange resin to produce block-copolymer of purified polyethylene glycol and poly(acidic amino acid). After protective group removing optionally purification is carried out by using of separating/adsorption resin, wherein content of contaminations comprising polyethylene glycol and poly(acidic amino acid) is not more than 10 mass %. Also disclosed are polymer carrier, method for production thereof, polymer pharmaceutical agent and assay for contaminant content.

EFFECT: improved method for contaminant removing; polymer carrier of pharmaceutically acceptable purity.

17 cl, 11 ex

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Authors

Nakanisi Takesi

Simizu Kazukhisa

Uekhara Riudzi

Suzuki Masanobu

Matida Megumi

Akutsu Tomoko

Fukusima Sigeto

Dates

2006-08-27Published

2002-06-19Filed