FIELD: organic chemistry, chemical technology, medicine, pharmacy.
SUBSTANCE: invention relates to a method for synthesis of aromatic sulfonyl halides by interaction of substituted phenolic compound with halogensulfonic acid and trifluoroacetic acid. Also, invention involves a method for synthesis of 4-[5-methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide of the formula (1) 
that is useful in treatment of disorders associated with cyclooxygenase-2 and involves interaction of a precursor-compound chosen from group consisting of compounds of the formula (2) 
and formula (3) 
with halogensulfonic acid in the presence of trifluoroacetic acid to yield a halogensulfonated compound, and interaction of a halogensulfonated compound with ammonium source to yield compound (isoxazol-4-yl)-benzenesulfonamide of the structural formula (1).
EFFECT: improved method of synthesis.
147 cl, 7 ex
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|
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