MODIFIERS OF GLYCOPROTEIN VI REPRESENTING NUCLEIC ACID Russian patent published in 2015 - IPC C12N15/11 C12N15/115 A61P7/02 

FIELD: bioengineering.

SUBSTANCE: ligand of glycoprotein VI (GPVI) is suggested, it represents nucleic acid interacting with glycoprotein of thrombocytes GPVI, and modulates its activity with regulation of thrombocytes function. The ligand has secondary structure containing in direction from 5' to 3' a first stalk, a first loop, a second stalk, a second loop, a third loop, a third stalk and a forth loop. The forth loop contains UAA. The ligand sequence is modified to increase resistance to nucleases. The ligand can be used for inhibition of the thrombocyte aggregation. Besides the modulators inhibiting the ligand activity with restoration of GPVI function are suggested. As well the invention relates to the compositions containing ligand or modulator intended for medical treatment of the thrombocytes-mediated disorders.

EFFECT: higher efficiency of medical treatment.

23 cl, 39 dwg, 7 tbl, 8 ex