3-AMINO-6,7-DIOXYGEN-CONTAINING STEROIDS, PHARMACEUTICAL COMPOSITION, METHODS FOR TREATMENT Russian patent published in 2007 - IPC C07J41/00 C07J71/00 A61K31/56 A61K31/57 A61K31/58 A61P37/08 A61P11/06 

FIELD: organic chemistry, steroids, medicine, pharmacy.

SUBSTANCE: invention describes compounds of the formula (I) , their pharmaceutically acceptable salts, solvates, stereoisomers wherein in each case R¹ and R² mean independently hydrogen atom, possibly substituted alkyl, aryl, heteroalkyl wherein heteroatom means nitrogen atom, heteroaryl wherein a heteroatom means nitrogen, oxygen or sulfur atom; or R¹ and R² in common with N-atom to which they are bound can form a heterocyclic structure as a moiety of organic group comprising 6-12 carbon atoms and comprising optionally 1-6 heteroatoms chosen from nitrogen and oxygen atoms; R³ and R⁴ mean hydrogen atom or a protective group under condition that R and/or R⁴ represents part of the hydroxyl protective group; № from 1 to 17 mean carbon atoms wherein C-atoms at № 1, 2, 4, 11, 12, 15 and 16 can be substituted with two from R⁵ groups; C17-atom can be substituted with one of the following groups: =C(R⁵)(R⁵), =C=C(R⁵)(R⁵) or two from groups - R⁵ and -OR⁶; C-atoms at № 5, 8, 9, 10, 13 and 14 can be substituted with group R⁵ wherein R means hydrogen atom (H), (C₁-C₆)-alkyl, (C₁-C₆)-hydroxyalkyl, (C₁-C₆)-halogenalkyl; R⁶ means H, protective group, such as -OR⁶-protected OH-group wherein the group -OR⁶ can form cyclic protective structure for vicinal -OH groups. Proposed compounds can be components of pharmaceutical composition and useful in treatment and/or prophylaxis of different states including inflammation, asthma, allergic disease, chronic obstructive pulmonary disease, allergic dermatitis, solid neoplasms, ischemia and cardiac arrhythmia.

EFFECT: improved treatment method, valuable medicinal properties of substances and pharmaceutical composition.

53 cl, 10 tbl, 24 ex