FIELD: chemistry; pharmaceutics.
SUBSTANCE: group of inventions relates to chemistry and pharmaceutics, specifically a compound of formula (I) or a pharmaceutically acceptable salt thereof, a pharmaceutical composition based thereon, having activity against respiratory syncytial virus (RS virus). In general formula (I), the dotted line indicates the presence or absence of a bond; R1 is carboxy, tetrazolyl or oxadiazolinyl; L is a substituted or unsubstituted 3–20-membered non-aromatic carbocyclyldiyl containing one ring or two or more rings, where the substituent group is selected from C1-C6 alkyl; hydroxy; cyano; C1-C6 alkyloxy and halogen; substituted or unsubstituted 5- or 6-member non-aromatic heterocyclyldiyl containing one or two oxygen atoms or nitrogen atoms, where the substituent group is selected from C1-C6 alkyloxycarbonyl; or substituted or unsubstituted C1-C6 alkylene, where the substituent group is selected from C1-C6 alkyl and C3-C6 member non-aromatic carbocyclyl; R2 is substituted or unsubstituted C1-C6 alkyl, where the substituent group is selected from halogen and hydroxy; R3 is a hydrogen atom; substituted or unsubstituted C1-C6 alkyl, where the substituent group is selected from amino, C1-C6 alkylamino, hydroxy and halogen; unsubstituted C1-C6 alkyloxy; or substituted or unsubstituted amino, where the substituent group is selected from C1-C6 alkyl; V is -CRV= or -N=; W is =CRW- or =N-;
is the structures specified below. Other values of radicals are given in the claim.
EFFECT: disclosed is an amide derivative having antiviral activity.
20 cl, 111 tbl, 23 ex
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Authors
Dates
2025-03-20—Published
2021-10-27—Filed