AMIDE DERIVATIVE HAVING ANTIVIRAL ACTIVITY Russian patent published in 2025 - IPC C07D209/18 C07D401/14 C07D403/04 C07D403/14 C07D405/12 C07D405/14 C07D409/14 C07D417/14 C07D471/04 C07D471/10 C07D487/04 C07D491/107 C07D491/20 C07D495/10 C07D519/00 A61K31/4045 A61K31/437 A61K31/4439 A61K31/444 A61K31/506 A61K31/5377 A61K31/4545 A61P31/14 

Abstract RU 2836730 C1

FIELD: chemistry; pharmaceutics.

SUBSTANCE: group of inventions relates to chemistry and pharmaceutics, specifically a compound of formula (I) or a pharmaceutically acceptable salt thereof, a pharmaceutical composition based thereon, having activity against respiratory syncytial virus (RS virus). In general formula (I), the dotted line indicates the presence or absence of a bond; R1 is carboxy, tetrazolyl or oxadiazolinyl; L is a substituted or unsubstituted 3–20-membered non-aromatic carbocyclyldiyl containing one ring or two or more rings, where the substituent group is selected from C1-C6 alkyl; hydroxy; cyano; C1-C6 alkyloxy and halogen; substituted or unsubstituted 5- or 6-member non-aromatic heterocyclyldiyl containing one or two oxygen atoms or nitrogen atoms, where the substituent group is selected from C1-C6 alkyloxycarbonyl; or substituted or unsubstituted C1-C6 alkylene, where the substituent group is selected from C1-C6 alkyl and C3-C6 member non-aromatic carbocyclyl; R2 is substituted or unsubstituted C1-C6 alkyl, where the substituent group is selected from halogen and hydroxy; R3 is a hydrogen atom; substituted or unsubstituted C1-C6 alkyl, where the substituent group is selected from amino, C1-C6 alkylamino, hydroxy and halogen; unsubstituted C1-C6 alkyloxy; or substituted or unsubstituted amino, where the substituent group is selected from C1-C6 alkyl; V is -CRV= or -N=; W is =CRW- or =N-;

is the structures specified below. Other values of radicals are given in the claim.

EFFECT: disclosed is an amide derivative having antiviral activity.

20 cl, 111 tbl, 23 ex

Similar patents RU2836730C1

Title Year Author Number
NITROGEN-CONTAINING TRICYCLIC DERIVATIVES HAVING HIV REPLICATION INHIBITION ACTIVITY 2016
  • Tamura, Yoshinori
  • Kawasuji, Takashi
  • Sugiyama, Shuichi
  • Matsumura, Akira
  • Akiyama, Toshiyuki
  • Tomida, Yutaka
RU2720145C2
6-MEMBERED HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME 2016
  • Tanaka, Satoru
  • Ogawa, Tomoyuki
  • Kai, Hiroyuki
  • Ogata, Yuki
  • Hirai, Keiichiro
  • Kurose, Noriyuki
  • Fujii, Yasuhiko
RU2683245C1
BENZIMIDAZOLE OR IMIDAZOPYRIDINE DERIVATIVES USEFUL FOR TREATING OR PREVENTING DISEASES ASSOCIATED WITH ACC2 2016
  • Iwatsu, Masafumi
  • Wada, Toshihiro
  • Sasaki, Yoshikazu
  • Miyazaki, Keisuke
  • Katou, Manabu
  • Nishiura, Yuji
  • Kurahashi, Kana
  • Ohyabu, Naoki
RU2702637C2
BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS INCLUDING THEM 2017
  • Masuda, Koji
  • Sugiyama, Shuichi
  • Yamada, Toru
  • Kojima, Eiichi
  • Ogawa, Tomoyuki
  • Kobayashi, Naotake
  • Kai, Hiroyuki
RU2753524C2
C17-, C20- AND C21-SUBSTITUTED NEUROACTIVE STEROIDS AND METHODS OF THEIR USE 2017
  • Robichaud, Albert, J.
  • Martinez Botella, Gabriel
  • Harrison, Boyd, L.
  • Salituro, Francesco, G.
  • Griffin, Andrew
  • Blanco-Pillado, Maria, Jesus
RU2828261C2
DRUG FOR INFLUENZA TREATMENT, CHARACTERIZED BY THE FACT THAT IT COMBINES A PER-DEPENDENT ENDONUCLEASE INHIBITOR AND A DRUG AGAINST FLU 2016
  • Sisido Takao
  • Nosi Takesi
  • Yamamoto Atsuko
  • Kitano Mitsutaka
RU2745071C2
SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF 2016
  • Kavaj Makoto
  • Tomita Kendzi
  • Akiyama Tosiyuki
  • Okano Azusa
  • Miyagava Masaesi
RU2712275C2
DIHYDROPYRAZOLOPYRAZINONE DERIVATIVE WITH MGAT-2 INHIBITORY ACTIVITY 2020
  • Tateno Yusuke
  • Katou Manabu
  • Wada Toshihiro
RU2803743C2
NEUROACTIVE STEROIDS SUBSTITUTED AT POSITION 10 WITH A CYCLIC GROUP FOR USE IN THE TREATMENT OF CNS DISORDERS 2019
  • Blanko-Pillado, Mariya, Khesus
  • Salituro, Franchesko, G.
  • Morningstar, Marshall, Li
RU2796006C2
ANTIVIRAL COMPOUNDS AND THEIR APPLICATION 2010
  • Rokuehj Todd V.
  • Betebenner Dehvid A.
  • Degoj Dehvid A.
  • Flentge Charl'Z A.
  • Khatchinson Duglas K.
  • Kati Uorren M.
  • Krjuger Allan K.
  • Lju Dachun'
  • Longeneker Kenton L.
  • Pratt Dzhon K.
  • Stjuart Kent D.
  • Vagner Rol'F
  • Maring Klarens Dzh.
RU2552533C2

RU 2 836 730 C1

Authors

Okano, Azusa

Tateno, Yusuke

Nodu, Kouhei

Suzuki, Shinji

Akiyama, Toshiyuki

Matoyama, Masaaki

Akaza, Hiroto

Fukuda, Takashi

Dates

2025-03-20Published

2021-10-27Filed