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(19)

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2 379 304

(13)

(51)

IPC

C07D401/14(2006-01-01)

A61K31/4709(2006-01-01)

A61P31/04(2006-01-01)

(21) (22)

Application

2007122499/04, 2005-11-17

(24)

Start date

2005-11-17

(22)

Actual filing date

2005-11-17

(45)

Published

2010-01-20

(72)

Inventor

Jazaki AkiraKuramoto JasukhiroItokh KendziJosikaj KazusaKhirao JuzoOkhsita JosikhiroKhajasi NorikhiroAmano KhirotakaAmago TakajukiTakenaka Khitomi

(73)

Holder

Vakunaga Farmas'Jutikal Ko., Ltd.

NEW DERIVATIVES OF PYRIDONECARBOXYLIC ACIDS OR SALTS THEREOF Russian patent published in 2010 - IPC C07D401/14 A61K31/4709 A61P31/04

Abstract RU 2379304 C2

FIELD: medicine.

SUBSTANCE: present invention concerns a derivative of pyridonecarboxylic acid presented by formula (1): or its salts where R¹ represents methyl group, fluorine atom or chlorine atom; R² represents hydrogen atom or lower alkyl group; R³ represents isopropyl group or tert-butyl group; R⁴ represents methyl group or halogen atom; and R⁵ represents fluorine atom or chlorine atom, and also an antibacterial preparation and a pharmaceutical composition, containing specified derivative or its salt as an active component. Besides the invention describes application of the compound under item 1 and the method of treating the infectious disease.

EFFECT: new compound shows excellent antibacterial activity, low toxicity, improved biological availability and low speed of binding with serum proteins.

10 cl, 4 ex, 4 tbl

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RU 2 379 304 C2

Authors

Jazaki Akira

Kuramoto Jasukhiro

Itokh Kendzi

Josikaj Kazusa

Khirao Juzo

Okhsita Josikhiro

Khajasi Norikhiro

Amano Khirotaka

Amago Takajuki

Takenaka Khitomi

Dates

2010-01-20—Published

2005-11-17—Filed