METHOD FOR PREPARING 1-[1-HYDROXY-1-(PYRID-4-YL)METHYL]-1,2-DIHYDRO[60]FULLERENES Russian patent published in 2007 - IPC C07D213/30 

Abstract RU 2294928 C2

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for synthesis of 1-[1-hydroxy-1-(pyrid-4-yl)methyl]-1,2-dihydro[60]fullerene. Method involves interaction of C60 with ethylaluminum dichloride and magnesium in the presence of catalyst, in argon atmosphere, at room temperature and under atmosphere pressure in medium of mixed solvent tetrahydrofuran-toluene for 8 h followed by addition nickel-containing catalyst and 4-pyridinecarbaldehyde to the reaction mass at -15°C. Then the reaction mass is stirred at room temperature for 6-10 h followed by its hydrolysis. The total yield of end substances after hydrolysis of the reaction mass is 33-52%. Invention provides the development of a method for synthesis of novel fullerene-containing alcohols. Synthesized compound can be used in fine organic synthesis, manufacture of drugs and biologically active substances.

EFFECT: improved method of synthesis.

1 tbl, 1 ex

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RU 2 294 928 C2

Authors

Dzhemilev Usein Memetovich

Ibragimov Askhat Gabdrakhmanovich

Khafizova Lejla Osmanovna

Makhamatkhanova Alevtina Leonidovna

Dzhmileva Galina Arkad'Evna

Muradymova Svetlana Maratovna

Dates

2007-03-10Published

2005-06-14Filed