FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to a method for synthesis of 1-[1-hydroxy-1-(pyrid-4-yl)methyl]-1,2-dihydro[60]fullerene. Method involves interaction of C60 with ethylaluminum dichloride and magnesium in the presence of catalyst, in argon atmosphere, at room temperature and under atmosphere pressure in medium of mixed solvent tetrahydrofuran-toluene for 8 h followed by addition nickel-containing catalyst and 4-pyridinecarbaldehyde to the reaction mass at -15°C. Then the reaction mass is stirred at room temperature for 6-10 h followed by its hydrolysis. The total yield of end substances after hydrolysis of the reaction mass is 33-52%. Invention provides the development of a method for synthesis of novel fullerene-containing alcohols. Synthesized compound can be used in fine organic synthesis, manufacture of drugs and biologically active substances.
EFFECT: improved method of synthesis.
1 tbl, 1 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD FOR PREPARING 1-[3-HYDROXY-3-(PYRID-4-YLPROP-1-YL]-1,2-DIHYDRO[60]FULLERENES | 2005 |
|
RU2294929C2 |
METHOD OF PREPARING 1-[3-HYDROXY-3-ARYLPROP-1-YL]-1,2-DIHYDRO[60]FULLERENES | 2005 |
|
RU2290367C1 |
METHOD FOR PREPARING 1-[1'-HYDROXY-1'-ALKYL-(1',1'-DIALKYL)]-METHYL-2-HYDRO[60]FULLERENES | 2003 |
|
RU2238263C1 |
METHOD FOR PREPARING 1-(DIALKOXYMETHYL)-2-HYDRO[60]FULLERENES | 2003 |
|
RU2240302C1 |
METHOD FOR PREPARING 1-[3-HYDROXY-4-(FUR-2-YL)PROP-1-YL]-1,2-DIHYDRO[60]FULLERENES | 2005 |
|
RU2290401C1 |
METHOD FOR PRODUCTION OF 1-HYDROXY-2,3-[60]FULLEROCYCLOPENTANECARBOXYLIC ACID ETHYL ESTER | 2005 |
|
RU2283830C1 |
METHOD FOR PRODUCTION OF 1-ETHENYL-1-METHYL-1-SILA-2,3-[60]FULLEROCYCLOPENTANE | 2005 |
|
RU2283844C1 |
METHOD OF OBTAINING POLYHYDRO[60]FULLERENES | 2007 |
|
RU2348604C1 |
METHOD OF PREPARING 1-ALKOXY-2,3-FULLERENE [60] ALUMACYCLOPROPANES | 1999 |
|
RU2160274C1 |
METHOD OF PREPARING 1-DIALKYLAMINE-2,3-FULLERENE [60] ALUMACYCLOPROPANES | 1999 |
|
RU2160271C1 |
Authors
Dates
2007-03-10—Published
2005-06-14—Filed