METHOD FOR PREPARING 1-[1-HYDROXY-1-(PYRID-4-YL)METHYL]-1,2-DIHYDRO[60]FULLERENES Russian patent published in 2007 - IPC C07D213/30 

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for synthesis of 1-[1-hydroxy-1-(pyrid-4-yl)methyl]-1,2-dihydro[60]fullerene. Method involves interaction of C₆₀ with ethylaluminum dichloride and magnesium in the presence of catalyst, in argon atmosphere, at room temperature and under atmosphere pressure in medium of mixed solvent tetrahydrofuran-toluene for 8 h followed by addition nickel-containing catalyst and 4-pyridinecarbaldehyde to the reaction mass at -15°C. Then the reaction mass is stirred at room temperature for 6-10 h followed by its hydrolysis. The total yield of end substances after hydrolysis of the reaction mass is 33-52%. Invention provides the development of a method for synthesis of novel fullerene-containing alcohols. Synthesized compound can be used in fine organic synthesis, manufacture of drugs and biologically active substances.

EFFECT: improved method of synthesis.

1 tbl, 1 ex