THIENOPYRIMIDINDIONS AND THEIR APPLICATION IN AUTOIMMUNE DISEASE MODULATION Russian patent published in 2008 - IPC C07D495/04 A61K31/519 A61P37/02 

FIELD: chemistry.

SUBSTANCE: (I) , in which R¹ and R² independently represent C_1-6alkyl, C_3-5cycloalkyl C_1-3alkyl or C_3-6dikloalkyl; Q represents CR⁴R⁵, where R⁴ represents hydrogen; or C_1-6alkyl, and R⁵ represents carbon; Ar represents 5-6-membered aromatic ring system, where heteroatoms can represent up to 2 ring atoms, independently selected from nitrogen and sulphur, notably that this ring system can be substituted by one or more then one substitute, independently selected from C_1-4alkyl; Ar² represents 5-6-membered aromatic ring system containing up to 2 ring atoms, independently selected from nitrogen and sulphur, notably the ring contains at least one heteroatom and can be substituted by one or more then one group, independently selected from C_1-4alkyl. The compositions can be used in autoimmune disease modulation. The methods of compounds production, pharmaceutical composition and use of the compounds in the treatment of respiratory disease are described.

EFFECT: production of thienopyrimidindion compounds for autoimmune disease modulation and respiratory disease treatment.

14 cl, 3 ex