THIENOPYRIMIDINE DIONES AND THEIR USE IN MODULATION OF AUTOIMMUNE DISEASE Russian patent published in 2008 - IPC C07D495/04 A61K31/519 A61P37/02 

FIELD: chemistry, pharmaceuticals.

SUBSTANCE: invention pertains to thienopyrimidine diones with general formula (I), , where R¹ and R² each independently represents C_1-6alkyl, C_3-5cycloalkylC_1-3alkyl or C_3-6cycloalkyl; R³ represents a CO-G group, where G is a 5- or 6-member ring, containing a nitrogen atom and a second oxygen heteroatom, adjacent to the nitrogen atom. This ring can be substituted by at least one group, chosen from C_1-4alkyl and hydroxyl; Q represents CR⁴R⁵, where R⁴ represents hydrogen or C_1-6alkyl, and R⁵ represents hydrogen; and Ar represents a 5-10-member aromatic ring system, where up to 3 ring atoms can represent heteroatoms, independently chosen from nitrogen and sulphur. This ring system can be substituted with one or more groups. The invention also relates to pharmaceutical salts and solvates of thienopyrimidine diones. Description is also given of the method of obtaining these compounds, pharmaceutical compositions containing them, and their use in therapy, particularly in immunosuppressive therapy.

EFFECT: obtaining thienopyrimidine diones for use in immunosuppressive therapy.

17 cl, 29 ex