SUBSTITUTED 4-ALKOXYOXAZOL DERIVATIVES AS PPAR AGONISTS Russian patent published in 2007 - IPC C07D263/32 C07D413/12 A61K31/421 A61K31/422 A61P3/10 A61P3/06 A61P9/02 A61P9/10 A61P35/00 A61P7/02 A61P15/00 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel compounds of the formula (I) and their pharmaceutically acceptable salts. Proposed compounds possess properties of agonists of receptors activated by peroxisome proliferators (PPAR agonists) and can be used in treatment of such diseases as diabetes mellitus, hypertension, atherosclerotic diseases and others. In the general formula (I) R¹ means lower alkyl, monocyclic (C₃-C₆)-cycloalkyl; R² means hydrogen atom, halogen atom, lower alkyl, lower alkoxy-group wherein at least one of three radicals R³, R⁴, R⁵ or R⁶ is not hydrogen atom; or R³ and R⁴ are bound together to form a ring with carbon atoms to which they are bound, and R³ and R⁴ mean in common -CH=CH-S-, -S-CH=CH-, -CH=CH-CH=CH-, and R⁵ and R⁶ are given above; R⁷ means lower alkyl, lower alkenyl; R⁸ means hydrogen atom or lower alkyl; n = 1, 2 or 3. Also, invention relates to a pharmaceutical composition based on the invention compounds and to using compounds of the invention in preparing medicinal agents used in treatment and/or prophylaxis of diseases mediated by agonists PPARα and/or PPARγ.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

20 cl, 1 tbl, 13 sch, 71 ex