INDOLE DERIVATIVES CONTAINING ACETYLENE GROUP AS PPAR ACTIVATORS Russian patent published in 2010 - IPC C07D209/08 A61K31/405 

FIELD: chemistry.

SUBSTANCE: invention relates to novel indole derivatives of formula I: , where: R¹ is H, C_1-7alkyl; R² and R³ independently represent H, C_1-7alkyl; R⁴ and R⁵ independently represent H, C_1-7alkyl, and one of R⁶, R⁷, R⁸ and R⁹ independently represents , where: X is O, NR¹³, (CH₂)_PNR¹³CO and (CH₂)_PCONR¹³; R¹³ is H, C_1-7alkyl; R¹⁰ is C_1-7alkyl; R¹¹ is H, C_1-7alkyl; R¹² is phenyl optionally mono- or multiple-substituted with CF₃, lower alkoxy group, lower alkyl, lower fluoroalkyl, lower fluoroalkoxy group, m, o, p equals 0, 1, 2; n equals 0, 1, 2, 3 and the sum of m, n and o ranges from 1 to 5; or their pharmaceutically acceptable salts.

EFFECT: formula I compounds have bonding activity with PPAR receptor.

25 cl, 7 dwg, 1 tbl, 22 ex