DERIVATIVES OF 4-(PHENYLPIPERAZINYLMETHYL)-BENZAMIDE, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2007 - IPC C07D401/06 C07D411/06 A61K31/496 A61P25/04

Abstract RU 2297412 C2

FIELD: organic chemistry, chemical technology, medicine, pharmacy.

SUBSTANCE: invention relates to derivatives of 4-(phenylpiperazinylmethyl)-benzamide of the general formula (I): or their salt, or separate enantiomers and their salts wherein R¹ means phenyl, pyridinyl, thienyl, furanyl, imidazolyl that can be substituted possibly; R² means ethyl and isopropyl; R³ means hydrogen, fluorine atom; R⁴ means -NH₂, -NHSO₂R⁵ wherein R⁵ means (C₁-C₆)-alkyl. Compounds are useful in therapy, in particular, in treatment of pain. Also, invention describes methods for synthesis of compounds of the formula (I) and a pharmaceutical composition based on thereof.

EFFECT: improved method of synthesis, valuable medicinal property of compounds and pharmaceutical composition.

12 cl, 1 tbl, 11 ex

Similar patents RU2297412C2

Title	Year	Author	Number
CONDENSED TRICYCLIC BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Aleksander Rikki Piter Kalmiano Mark Daniel Defejs Sabine Dyure Veronik Delini Mikhael Kher Yag Paul Dzhekson Viktoriya Elizabet Keje Zhan Kroplin Boris Mak-Koss Malkolm Sabnis Jogesh Anil Selbi Mattyu Dankan Svinnen Dominik Lui Leon Van-Khautvin Natali Chzhu Chzhaonin Vener Folkmar Khajnelt Uve	RU2689777C1
FUSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Aleksander Rikki Piter Brejs Garet Nil Braun Dzhulien Alister Kalmiano Mark Daniel Chovatiya Praful Tulshi Delini Mikhael Gallimor Ellen Oliviya Kher Yag Paul Dzhekson Viktoriya Elizabet Kroplin Boris Mak-Koss Malkolm Kuinsi Dzhoanna Rejchel Sabnis Jogesh Anil Svinnen Dominik Lui Leon Chzhu Chzhaonin Khajnelt Uve Vener Folkmar	RU2679914C9
DERIVATIVES OF INDANE ACETIC ACID AND PHARMACEUTICAL COMPOSITION	2002	Lou Derek B. Vikens Filip L. Ma Ksin Zhang Mingbao Ballok Villiam Kh. Kojsh Filip D.G. Mugge Ingo A. Shtolle Andreas Vang Ming Vang Jamin Zhang Chengzhi Zhang Khaj-Jun Zhu Lej Tsutsumi Manami Lajvingston Dzhejms N.	RU2314298C2
NOVEL COMPOUNDS OF CONDENSED IMIDAZOLE POSSESSING OF CB2 RECEPTOR AGONIST PROPERTY	2002	Cheng Jun-Ksing Tomashevski Miroslav Uolpol Kristofer Jang Kh'Juehj	RU2312864C2
NEW COMPOUNDS - NEUROKININ 1 RECEPTOR ANTAGONIZER	2013	Serensen Morten Dal Di Fabio Romano Potstsan Alfonso Katalani Mariya Piya Bladkh Khokon Felding Yakob	RU2631319C2
COMPOUNDS OF FORMULA (I) AND FORMULA (A), PHARMACEUTICAL COMPOSITION, MEDICINAL PRODUCT, USE AND METHOD OF OBTAINING COMPOUNDS OF FORMULA (I)	2018	Krosinyani, Stefano Gomes, Bruno Khautkhejs, Erika	RU2822758C2
PYRAZOLOPYRIDINE DERIVATIVES AS KINASE INHIBITORS	2015	Ford Daniel Dzhejms Ryuberson Dzhejms Tomas	RU2733400C2
DERIVATIVES OF 2,4-SUBSTITUTED PHENYLENE-1,5-DIAMINE AND THEIR USES, PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS OBTAINED FROM THEM	2015	Lan Tszyun Tszin Yunchzhou Chzhou Fushen Se Tszin Shen Sida Khu I Lyu Vej Lv Tsyan	RU2649001C1
DERIVATIVES OF THIOPHENE	2003	Ehndrjus Klarens U. Tretij Chijung M'Jui Dehjvis-Uord Ronda Dzh. Druri Dejvid Kharol'D Ehmmitt Kajl Allen Khabbard Robert Dejl Kunts Kevin U. Linn Dzhejms Ehndrju Muk Robert Ehntoni Smit Gehri Kejt Vil Dzhejms Marvin	RU2296758C2
6-HETEROCYCLYL-4-MORPHOLINE-4-ILPYRIDINE-2-ONES SUITABLE FOR THE TREATMENT OF CANCER AND DIABETES	2017	Martinsson, Dzhessika Andersson, Martin Lindstrem, Jokhan Forsblom, Rikard Ram, Fredrik Jinman, Tobias Viklund, Jenni	RU2762968C2

RU 2 297 412 C2

Authors

Braun Uil'Jam

Uolpol Kristofer

Plobek Niklas

Dates

2007-04-20—Published

2002-05-16—Filed