DERIVATIVES OF THIOPHENE Russian patent published in 2007 - IPC C07D409/04 C07D409/14 A61K31/4184 A61P35/00 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to derivatives of thiophene of the general formula (I): , wherein R¹ is chosen from group consisting of hydrogen atom (H), -C(O)R⁷, -CO₂R⁷, -C(O)NR⁷R⁸, -C(O)N(R⁷)OR⁸, -C(O)N(R⁷)-R²-OR⁸, -C(O)N(R⁷)-Ph, -C(O)N(R⁷)-R-Ph, -C(O)N(R⁷)S(O)₂R⁸, -R²-OR⁷, -R²-O-C(O)R⁷, -C(S)R⁷, -C(S)NR⁷R⁸, -C(S)N(R⁷)-Ph, -C(S)N(R⁷)-R²-Ph, -R²-SR⁷, -CN, -OR⁷ and Het wherein Het represents tetrazolyl; Q¹ represent group of the formula: -(R²)_a-(Y¹)_b-(R²)_c-R³ wherein a, b and a are similar or different and each means independently 0 or 1, and at least one among a or b means 1; n means 0, 1, 2, 3 or 4; Q² represents group of the formula: -(R²)_aa-(Y²)_bb-(R²)_cc-R⁴, or two adjacent Q² groups represent -OR⁷ and in common with carbon atoms to which they are bound form 5-7-membered heterocycle comprising 1 or 2 heteroatoms chosen from oxygen atom (O); R⁵ is chosen from group consisting of H, alkyl and -NR⁷R⁸, or their pharmaceutically acceptable salts and solvates. Compounds can be used in treatment of states mediated by Polo-like kinase and sensitive neoplasm. Also, invention describes a method for synthesis of these compounds and preparing pharmaceutical compositions based on thereof.

EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions.

27 cl, 1 tbl, 199 ex