2-HETEROCYCLYL-1,2-ETHANEDIOL CARBAMATES Russian patent published in 2007 - IPC C07D333/42 C07D277/46 C07D213/56 A61K31/28 A61P25/08

Abstract RU 2298552 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to 2-heterocyclyl-1,2-ethanediol carbamates of the formula (I) , their enantiomers, enantiomeric mixtures or pharmaceutically acceptable salts wherein A means a heterocyclic fragment chosen from the following group:

B₁ and B₂ mean independently hydroxy-group or -OCONR₁R₂ under condition that B₁ and B₂ don't mean hydroxy-group simultaneously; R₁ and R₂ mean hydrogen atom; R₃, R₄ and R₅ mean alkyl, halogen atom, trihalogenmethyl, trialkylmethyl, -NO₂, -CN and phenyl. These compounds can be used in treatment of the central nervous system disorders being especially as anticonvulsants and anti-epileptic agents. Also, invention describes a pharmaceutical composition based on compounds of the formula (I).

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

12 cl, 1 tbl, 34 ex

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RU 2 298 552 C2

Authors

Choj Jong-Moon

Li Ki-Kho

Dates

2007-05-10—Published

2002-06-18—Filed