NOVEL WATER-SOLUBLE PRODRUGS Russian patent published in 2011 - IPC C07D491/22 A61K31/519 A61P1/00 A61P11/00 A61P13/10 A61P15/00 A61P31/10 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: prodrugs are represented by formula or in which in formula (2) R¹ represents an atom of hydrogen or C1-C6-alkyl group; X is C=O or C1-C3 slkylene group; R² and R⁴ each independently represents a hydrogen, C1-C6-alkyl group; and R³ is C1-C6 alkyl group, and in formula (3) R¹ has values specified in formula (2); n is an integer from 1 to 6; and R⁵ is a hydrogen atom or -COOR⁶ (where R⁶ is a hydrogen atom or C1-C6 alkyl group), where in formula (2) and (3) Y is a group, represented by formula (5), which is given in the invention formula.

EFFECT: obtaining novel water-soluble prodrugs, which cam be introduced parenterally, and which demonstrate high solubility in water are quickly turned into an active form.

12 cl, 7 tbl, 14 ex