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2 299 740

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IPC

A61K36/484(2006-01-01)

A61P11/06(2006-01-01)

A61P31/12(2006-01-01)

A61P17/00(2006-01-01)

A61P27/14(2006-01-01)

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Application

2005113361/15, 2005-05-03

(24)

Start date

2005-05-03

(22)

Actual filing date

2005-05-03

(45)

Published

2007-05-27

(72)

Inventor

Kondratenko Rimma MinibaevnaBaltina Lidija AshrafovnaStoljarova Ol'Ga VladimirovnaBaltina Lija AleksandrovnaMikhajlova Lilija RafailovnaGabbasov Tagir MazitovichGalin Fanur ZufarovichTolstikov Genrikh Aleksandrovich

(73)

Holder

Institut Organicheskoj Khimii Ufimskogo Nauchnogo Tsentra RanNovosibirskij Institut Organicheskoj Khimii Im. N.N. Vorozhtsova So Ran

METHOD FOR PREPARING GLYCYRRHIZIC ACID MONOAMMONIUM SALT (GLYCYRAM) Russian patent published in 2007 - IPC A61K36/484 A61P11/06 A61P31/12 A61P17/00 A61P27/14

Abstract RU 2299740 C2

FIELD: medicinal plants, chemical technology.

SUBSTANCE: method involves extraction of milled licorice (Glycyrrhiza uralensis, Fischer) roots with 0.5% aqueous solution of NH₄OH. The total triterpene acids of extract are precipitated with concentrated H₂SO₄ followed by extraction of total triterpene acids with 1% solution of H₂SO₄ in acetone, precipitation of glycyrrhizic acid triammonium salt with 25% solution of NH₄OH and its conversion to monoammonium salt by re-crystallization from glacial CH₃COOH and purification of the latter by re-crystallization from 85% ethanol. Invention provides enhanced yield of the end product.

EFFECT: improved preparing method, enhanced yield.

1 dwg, 1 ex

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RU 2 299 740 C2

Authors

Kondratenko Rimma Minibaevna

Baltina Lidija Ashrafovna

Stoljarova Ol'Ga Vladimirovna

Baltina Lija Aleksandrovna

Mikhajlova Lilija Rafailovna

Gabbasov Tagir Mazitovich

Galin Fanur Zufarovich

Tolstikov Genrikh Aleksandrovich

Dates

2007-05-27—Published

2005-05-03—Filed