CONFORMATIONAL ANOMALOUS FORMS OF TAU PROTEINS AND SPECIFIC ANTIBODIES TO THEM Russian patent published in 2007 - IPC C07K16/18 C12N5/16 C07K14/435 G01N33/577 A61K39/395 A61P25/28 

FIELD: immunology, biotechnology.

SUBSTANCE: invention relates to antibodies showing specificity to anomalous processed form of human tau protein that differs by conformation from the normal tau protein and doesn't bind with normal tau protein. Also, invention relates to conformational distinctive tau proteins ("tauones") and diagnostic and therapeutic aspects related to Alzheimer's disease and related taupathies. Proposed antibodies are produced by hybridomas DC-11 or Dc-11/1 deposited in ECACC at numbers 00082215 and 00082216. Also, invention described truncated forms of human tau protein that are truncated by N- and/or C-end and comprise amino acid residues from amino acid 300 to amino acid 400 in the longest isoform of human tau protein (441 amino acids residues). Above mentioned truncated forms of human tau protein can be recognized specifically by antibodies described above. Also, invention describes a method for assay of truncated forms of tau protein in a patient biological sample using a set comprising a proposed antibody and suitable container. Using the proposed invention provides a suitable target for medicinal preparations with early therapeutic effect used in Alzheimer's disease and other taupathies.

EFFECT: valuable medicinal properties of proteins.

11 cl, 15 dwg, 10 ex