THERAPY AND DIAGNOSTICS BASED ON PROTEINS OF TAU-MEDIATED PATHOLOGY IN ALZHEIMER DISEASE Russian patent published in 2018 - IPC A61K39/395 C07K16/18 

FIELD: biotechnology.

SUBSTANCE: invention relates to unique therapeutic and diagnostic antibodies and their fragments, parts, derivatives and options that bind the tau-protein areas, who participate in the initiation and development of pathological tau-tau interactions, as well as to methods of their production. The invention also relates to methods of using these antibodies for the diagnostics, prevention and treatment of Alzheimer disease and related tauopathies. In addition, the invention relates to a method of preventive and therapeutic treatment of Alzheimer disease and other neurodegenerative tauopathies. This method covers the injection of antibodies and/or peptide vaccines that induce an immune response directed at pathological tau-proteins and tau-protein deposits in the brain of patients. These vaccines contain a tau-peptide having one or more of the therapeutic epitopes contemplated within the scope of the invention.

EFFECT: invention provides effective prevention and treatment of Alzheimer disease.

34 cl, 83 dwg, 1 tbl, 27 ex