FIELD: medicine.
SUBSTANCE: group of inventions relates to therapy, and is intended for the treatment of diseases associated with HDAC6. Derivatives of 1,2,4-oxadiazole of formula (I) and their use for the treatment of diseases associated with HDAC6 and selected from cancer, autoimmune or inflammatory disease, transplant rejection, ciliopathy, nervous system disease, mental or behavioral disorder, infectious disease, cardiovascular disease, muscle atrophy and cachexia, namely from peripheral neuropathy and Charcot-Marie-Tooth disease are presented. In another embodiment, a pharmaceutical composition containing the said compounds is provided. Also an in vitro method for inhibiting HDAC6 and an in vitro use of 1,2,4-oxadiazole derivatives of formula (I) as an HDAC6 inhibitor are provided.
EFFECT: group of inventions provides new derivatives of 1,2,4-oxadiazole of formula (I) with inhibitory activity against histone deacetylase 6 (HDAC6).
32 cl, 1 tbl, 9 ex
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Authors
Dates
2023-06-07—Published
2018-12-05—Filed