1,2,4-OXADIAZOLE DERIVATIVES AS HISTONEDEACETILASE 6 INHIBITORS Russian patent published in 2023 - IPC A61K31/4245 A61K31/444 A61K31/437 A61K31/5377 A61K45/06 A61P25/00 A61P9/00 A61P21/00 A61P29/00 A61P31/00 A61P35/00 A61P37/06 C07D413/14 C07D471/04

Abstract RU 2797613 C2

FIELD: medicine.

SUBSTANCE: group of inventions relates to therapy, and is intended for the treatment of diseases associated with HDAC6. Derivatives of 1,2,4-oxadiazole of formula (I) and their use for the treatment of diseases associated with HDAC6 and selected from cancer, autoimmune or inflammatory disease, transplant rejection, ciliopathy, nervous system disease, mental or behavioral disorder, infectious disease, cardiovascular disease, muscle atrophy and cachexia, namely from peripheral neuropathy and Charcot-Marie-Tooth disease are presented. In another embodiment, a pharmaceutical composition containing the said compounds is provided. Also an in vitro method for inhibiting HDAC6 and an in vitro use of 1,2,4-oxadiazole derivatives of formula (I) as an HDAC6 inhibitor are provided.

EFFECT: group of inventions provides new derivatives of 1,2,4-oxadiazole of formula (I) with inhibitory activity against histone deacetylase 6 (HDAC6).

32 cl, 1 tbl, 9 ex

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RU 2 797 613 C2

Authors

Carceller Gonzalez, Elena

Ortega Munoz, Alberto

Salas Solana, Jorge

Dates

2023-06-07—Published

2018-12-05—Filed