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(19)

(11)

2 301 231

(13)

(51)

IPC

C07D401/14(2006-01-01)

C07D413/14(2006-01-01)

C07D401/12(2006-01-01)

C07D409/14(2006-01-01)

C07D417/14(2006-01-01)

C07D213/73(2006-01-01)

A61K31/4545(2006-01-01)

A61K31/4523(2006-01-01)

A61K31/506(2006-01-01)

A61K31/4709(2006-01-01)

A61K31/497(2006-01-01)

A61K31/498(2006-01-01)

A61K31/5377(2006-01-01)

A61P37/08(2006-01-01)

A61P11/00(2006-01-01)

A61P3/00(2006-01-01)

A61P25/00(2006-01-01)

A61P25/18(2006-01-01)

A61P25/28(2006-01-01)

(21) (22)

Application

2003114748/04, 2001-10-15

(24)

Start date

2001-10-15

(22)

Actual filing date

2001-10-15

(45)

Published

2007-06-20

(72)

Inventor

Aslanjan Robert Dzh.Shikh Neng-JangTing Poulin K.Berlin Majkl J.Rozenbljum Stjuart B.Mak Kormik Kevin D.Tom Ving K.Bojs Kristofer V.Mangiarasina P'EtroMutakhi Mvangi VaPivinski Dzhon Dzh.

(73)

Holder

Shering Korporejshn

POLYCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION POSSESSING PROPERTY OF H RECEPTOR ANTAGONIST AND METHOD FOR TREATMENT BY ITS USING Russian patent published in 2007 - IPC C07D401/14 C07D413/14 C07D401/12 C07D409/14 C07D417/14 C07D213/73 A61K31/4545 A61K31/4523 A61K31/506 A61K31/4709 A61K31/497 A61K31/498 A61K31/5377 A61P37/08 A61P11/00 A61P3/00 A61P25/00 A61P25/18 A61P25/28

Abstract RU 2301231 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel polycyclic compounds of the formula (I): wherein radicals and symbols have values given in the invention claim. Compounds of the formula (I) possess properties of H₃ receptors antagonist. Also, invention relates to a pharmaceutical composition containing compounds of the formula (I). Also, invention relates to a method for treatment of disease of group comprising difficulty in nasal breath, obesity, somnolence, narcolepsy, attention deficiency with hyperactivity, Alzheimer's disease and schizophrenia that involves using compounds of the formula (I) and, optionally, in combination of H receptor antagonist.

EFFECT: valuable medicinal properties of compound and pharmaceutical composition.

39 cl, 3 tbl, 31 ex

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RU 2 301 231 C2

Authors

Aslanjan Robert Dzh.

Shikh Neng-Jang

Ting Poulin K.

Berlin Majkl J.

Rozenbljum Stjuart B.

Mak Kormik Kevin D.

Tom Ving K.

Bojs Kristofer V.

Mangiarasina P'Etro

Mutakhi Mvangi Va

Pivinski Dzhon Dzh.

Dates

2007-06-20—Published

2001-10-15—Filed