FIELD: chemistry.
SUBSTANCE: invention pertains to new hetero-aryl derivatives of 8-azabicyclo-[3.2.1]-octan-3-ol with general formula I 
where R-R4 represent hetero-aryl. The hetero-aryl is in form of a cyclic aromatic group with C5-C6 or a bicyclic group with C9-C10, which contain 1, 2 or 3 hetero atoms, independently O, S or N, or a residue of 
, R1-H, C1-C6-akyl, R2 and R3 independently CH3, -OCH3, F, Cl, Br, J, R4 - from 1 to 4 substitutes, -H, halogen, C1-C6alkyl, -CF3, -OCF3, -(CH2)n-OR5, -(CH2)n-NR5R6, -(CH2)n-NHSO2R5, -(CH2)n-NH(CH2)2NR5R6, -(CH2)n-NHC(O)NR5R7, -(CH2)n-NH(CH2)2OR5, or 1-piperazinyl; n - 0, 1, 2, 3; R5 and R6 - H, C1C3alkyl, R7-H, C1-C3alkyl, aminoalkyl C1-C3, or to their pharmaceutical salts. The compounds are antagonists of the nociceptin ORL-1 receptor.
EFFECT: obtaining of compounds that are useful in the treatment of cough.
10 cl, 22 ex, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| AZABICYCLIC AND DIAZEPINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISORDERS | 2018 |
|
RU2795521C2 |
| FUSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | 2014 |
|
RU2679914C9 |
| CONDENSED DERIVATIVES OF IMIDAZOLE AND PYRAZOLE AS MODULATORS OF ACTIVITY TNF | 2014 |
|
RU2686117C1 |
| CONDENSED TRICYCLIC BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | 2014 |
|
RU2689777C1 |
| MACROCYCLIC COMPOUNDS AS STING AGONISTS AND METHODS USING THEM AND WAYS OF USE THEREOF | 2020 |
|
RU2825271C2 |
| HETEROCYCLIC MUSCARINIC AGONISTS AND COMPOSITIONS, THEIR USING AND METHODS FOR TREATMENT | 2002 |
|
RU2292346C2 |
| DERIVATIVES OF BENZIMIDAZOLIDINONE AS AGENTS FOR MUSCARINIC RECEPTORS | 2002 |
|
RU2288919C2 |
| CYCLIC AMINE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | 2011 |
|
RU2565596C2 |
| ISOQUINOLINONE DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH POLY(ADP-ribose)POLYMERASE-1, CONTAINING THEM AS ACTIVE INGREDIENT | 2020 |
|
RU2815480C1 |
| PHARMACEUTICAL COMPOUNDS | 2018 |
|
RU2767857C2 |
