FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to substituted diketopiperazines of the general formula (I) 
or their physiologically acceptable salts wherein R1 means 5-membered cycloalkyl group optionally substituted with one or some hydroxyl groups that is condensed with optionally substituted benzene ring; R2 means (C1-C6)-alkyl; R3 means optionally substituted phenyl, 5- or 6-membered heteroaryl group, or condensed bicyclic ring system comprising 9-10 ring members; R4 means -OH, -O-(C1-C4)-alkyl or -NR5R6. Compounds possess antagonistic effect with respect to oxytocin in oxytocin receptors. Also, invention describes a pharmaceutical composition based on compound of the formula (I), using compounds of the formula (I) for preparing a medicinal agent and methods for synthesis of compounds of the formula (I).
EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.
16 cl, 227 ex
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