FIELD: medicine; biochemistry.
SUBSTANCE: group of inventions relates to biochemistry and medicine, particularly to novel bicyclic heterocyclic compounds which are apoptosis protein (IAP) inhibitors (IAP) antagonists, to pharmaceutical compositions based thereon, methods of producing and using said compounds in preventing or treating IAP mediated diseases. Compound has a structure of formula (I)
EFFECT: compounds of formula (I) are antagonists of IAP family proteins, and especially XIAP and/or cIAP, such as cIAP1 and/or cIAP2, and can be used in treating IAP-mediated conditions, including cancer characterized by overexpression of at least one IAP and/or amplification of 11q22.
62 cl, 17 dwg, 2 tbl, 45 ex
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