FIELD: medicine, immunology, pharmacy.
SUBSTANCE: invention relates to antibody, drug based on thereof used in treatment or diagnosis of infection caused by microorganism expressing of the protein GrfA homolog. Also, invention discloses a method for preparing a drug said and a pharmaceutical package used in treatment of the diseases said. The described antibody shows the established amino acid sequence represented as the sequence SEQ ID NO:2 given in the description, and antibody or its antigen-binding fragment that binds specifically with epitope allowing by peptide with amino acid sequence given in SEQ ID NO:3 and disclosed in the description. Using the invention provides enhancing the therapeutic effectiveness of a glycopeptide antibiotic as compared with using a single antibiotic.
EFFECT: enhanced effectiveness of infection.
22 cl, 1 dwg, 10 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIBODIES AGAINST TEICHOIC ACID CONJUGATE AND THEIR CONJUGATES | 2014 |
|
RU2687044C2 |
| ANTI-PBP2A PROTEIN MONOCLONAL ANTIBODIES AND HOMOLOGOUS SEQUENCES FOR TREATING BACTERIAL INFECTION AND IMMUNODIAGNOSIS OF Firmicutes BACTERIA | 2010 |
|
RU2575070C2 |
| COMBINATIONS OF BACTERIOPHAGE LYSINE AND ANTIBIOTICS AGAINST GRAM-POSITIVE BACTERIA | 2013 |
|
RU2659208C2 |
| STAPHYLOCOCCUS AUREUS LEUKOCIDINS, THERAPEUTIC COMPOSITIONS AND THEIR APPLICATION | 2011 |
|
RU2677140C1 |
| STAPHYLOCOCCUS AUREUS LEUKOCIDINS, THERAPEUTIC COMPOSITIONS AND THEIR USE | 2018 |
|
RU2795545C2 |
| STAPHYLOCOCCUS AUREUS LEUKOCIDINS, THERAPEUTIC COMPOSITIONS AND THEIR APPLICATION | 2011 |
|
RU2644237C2 |
| COMPLEXES OF NUCLEIC ACIDS | 2011 |
|
RU2568829C2 |
| COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF INFECTIONS CAUSED BY STAPHYLOCOCCUS AUREUS | 2015 |
|
RU2636780C1 |
| BIOFILM PREVENTION, DESTRUCTION AND TREATMENT BY BACTERIOPHAGE LYSIN | 2013 |
|
RU2646102C2 |
| PREVENTION, DESTRUCTION AND TREATMENT OF BIOFILM BY BACTERIOPHAGE LYSINE | 2013 |
|
RU2735103C2 |
