BIOFILM PREVENTION, DESTRUCTION AND TREATMENT BY BACTERIOPHAGE LYSIN Russian patent published in 2018 - IPC A61K38/16 A61K39/85 A61K39/09 C12N9/52 A61L29/08 A61L29/16 

FIELD: biotechnology.

SUBSTANCE: methods include contacting of a biofilm comprising one or more of Staphylococcus or Streptococcus, with a composition comprising an effective amount of a lysin polypeptide comprising the amino acid sequence of SEQ ID NO: 1 or versions thereof having at least 80% identity to the SEQ ID NO: 1 polypeptide and being effective for staphylococcal and streptococcal bacteria lysis in a biofilm. The biofilm is effectively dispersed or treated. The inventions allow to eliminate not only mature biofilms, but also to prevent formation of de novo biofilms.

EFFECT: lysin polypeptide used demonstrates high activity at lower concentrations compared to the lack of activity of antibiotics used at high concentrations.

21 cl, 21 dwg, 7 tbl, 14 ex