FIELD: organic chemistry, chemical technology, antibiotics.
SUBSTANCE: invention relates to an improved method for synthesis of benzyl-penicillin diethylaminoethyl ester hydroiodide. Method involves interaction of benzyl-penicillin alkaline salt with N-(2-chloroethyl)-diethylamine in acetonitrile or N,N-dimethylformamide medium in the presence of hydroiodic acid alkaline metal salt followed by distilling off acetonitrile or N,N-dimethylformamide under vacuum and crystallization of benzyl-penicillin diethylaminoethyl ester hydroiodide in acetone medium. The crystallization process of benzyl-penicillin diethylaminoethyl ester hydroiodide is carried out in the presence of phosphoric acid alkaline metal salts wherein a mixture of potassium dihydrogen phosphate and sodium hydrogen phosphate as phosphoric acid alkaline metal salts are used in the amount 0.5-1.0% of benzyl-penicillin alkaline salt mass charged to the esterification process reaction mass. Method provides enhancing stability of aqueous suspension prepared with using product synthesized on the basis of invention claimed.
EFFECT: improved method of synthesis.
2 cl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF SYNTHESIS OF BENZYLPENICILLIN DIETHYLAMINOETHYL ESTER HYDROIODIDE | 2000 |
|
RU2167162C1 |
| 0 |
|
SU461509A3 | |
| METHOD OF OBTAINING N-(ISO)NICOTINOYL- γ -AMINOBUTYRIC ACID AND ITS SODIUM OR POTASSIUM SALT | 2007 |
|
RU2337097C1 |
| PENICILLIN PRODUCING METHOD | 0 |
|
SU626703A3 |
| METHOD FOR PREPARING WATER-SOLUBLE PHOSPHONOOXYMETHYL DERIVATIVES OF ALCOHOL AND PHENOL | 2002 |
|
RU2310659C2 |
| PROCESS FOR PREPARING BIS(β-CHLOROETHYL)VINYL PHOSPHONATE | 1992 |
|
RU2076868C1 |
| METHOD OF PREPARING N-AMINOBENZOIC ACID ESTERS | 1995 |
|
RU2089541C1 |
| 0 |
|
SU289596A1 | |
| METHOD OF PREPARING SUCRALOSE WITHOUT INTERMEDIATE ISOLATION OF CRYSTALLINE SUCRALOSE 6-ETHER | 1995 |
|
RU2155769C2 |
| METHOD OF SYNTHESIS OF CRYSTALLINE 7-[2-(2- AMINOTHIAZOLE-4-YL) -2-(Z)-METHOXYIMINOACETAMIDO]-3- [(-1-METHYL-1- PYRROLIDINIO) -METHYL]- CEPH-3-EM -4-CARBOXYLATE MONO- OR DIHYDRATE DIHYDROCHLORIDE ESSENTIALLY FREE FROM ANTIISOMER AND Δ-ISOMER | 1992 |
|
RU2042681C1 |
