FIELD: medicine.
SUBSTANCE: invention relates to application of pyrazoline derivatives of general formula I 
for prevention and/or treatment of precancerous or neoplastic processes, tumor angiogenesis, processes, associated with tumor necrosis factor (TNF) and other processes wherein inhibition of gene expression responsible to cyclooxygenase-2 (COX-2) synthesis in mammalian, including human has beneficial action.
EFFECT: new derivatives for prevention and/or treatment of diseases associated with cell proliferation.
3 cl, 2 tbl, 10 ex
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