ALBUMIN SOLUTION AND METHOD FOR PRODUCTION THEREOF Russian patent published in 2007 - IPC A61K38/38 A61K35/14 

FIELD: albumin solution treated to virus inactivate useful in therapy and method for production thereof.

SUBSTANCE: claimed method includes a) treatment of the first aqueous albumin solution to virus inactivate using SD (solvent/detergent) method by contacting with SD reagents at temperature lower 45°C; b) SD reagent removing by oil extraction followed by chromatography of hydrophobic interaction wherein hydrophobic matrix, in particular matrix wherein hydrophobic groups may optionally bond thereto, is used in said chromatography with the proviso that abovementioned groups represent aliphatic C24+-groups, to produce the second albumin solution; optionally c) addition to the second solution one or more stabilizers selected from group containing sugars, amino acids, and sugar alcohol wherein as said stabilizer indole stabilizer and C₆-C₁₀-fatty acid are not used; and d) finished packing of optionally stabilizer-containing second solution followed by sterilizing filtration and optionally container filling therewith. Albumin solution of present invention has binding ability by 10 % higher in contract with albumin treated by pasteurization.

EFFECT: albumin solution with increased binding ability.

18 cl, 3 dwg, 1 ex