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2 306 313

(13)

(51)

IPC

C07D487/04(2006-01-01)

A61K31/505(2006-01-01)

A61P37/08(2006-01-01)

A61P35/00(2006-01-01)

A61P11/06(2006-01-01)

A61P7/02(2006-01-01)

(21) (22)

Application

2002132193/04, 2001-04-17

(24)

Start date

2001-04-17

(22)

Actual filing date

2001-04-17

(45)

Published

2007-09-20

(72)

Inventor

Jura TakeshiKonseps'On Arnel' B.Khan GionkhiMarumo MakikoKatsumata KhirokoKavamura NorikhiroKokubo ToshioKomura KhiroshiLi JungfuLovinger Timoti B.Mogi MunetoJamamoto NorijukiJoshida NagakhiroMiller SkottPopp Margaret Eh.Redmann Aniko M.Rodriges Marta E.Skott Vil'JamVang Ming

(73)

Holder

Bajer Aktsiengezel'Shaft

IMIDAZO(OR TRIAZOLO)PYRIMIDINE DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL AGENT INHIBITING SYK TYROSINE KINASE ACTIVITY Russian patent published in 2007 - IPC C07D487/04 A61K31/505 A61P37/08 A61P35/00 A61P11/06 A61P7/02

Abstract RU 2306313 C2

FIELD: organic chemistry, drugs.

SUBSTANCE: invention relates to imidazo(or triazolo)pyrimidine derivatives of general formula I wherein Y represents CH or N; R¹, R² and R³ are as defined in the description, and pharmaceutically acceptable salt thereof. Such compounds inhibit SYK tyrosine kinase and are useful in medicine to suppress immediate allergic reaction and late inflammation reaction. Described is method for production of abovementioned compounds by interaction of compound of formula II wherein Y, R² and R³ are as defined above; L is leaving group, with compound of formula III: HR¹, wherein R¹ is as defined above. Also disclosed is pharmaceutical agent inhibiting SYK tyrosine kinase activity.

EFFECT: new inhibitors of SYK tyrosine kinase activity.

7 cl, 17 tbl, 17 ex

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RU 2 306 313 C2

Authors

Jura Takeshi

Konseps'On Arnel' B.

Khan Gionkhi

Marumo Makiko

Katsumata Khiroko

Kavamura Norikhiro

Kokubo Toshio

Komura Khiroshi

Li Jungfu

Lovinger Timoti B.

Mogi Muneto

Jamamoto Norijuki

Joshida Nagakhiro

Miller Skott

Popp Margaret Eh.

Redmann Aniko M.

Rodriges Marta E.

Skott Vil'Jam

Vang Ming

Dates

2007-09-20—Published

2001-04-17—Filed