WATER-GLYCEROL COMPLEX BASED ON (2,3-DIOXYPROPYL)ORTHOTITANATE-SILICATE AND PHARMACEUTICAL COMPOSITION Russian patent published in 2007 - IPC C07F7/28 A61K31/47 A61P17/00 A61K9/10

Abstract RU 2306317 C2

FIELD: organic chemistry, medicine, veterinary.

SUBSTANCE: described is complex based on (2,3-dioxypropyl)ortho-titanate-silicate of formula Ti-[O-CH₂-CH(OH)-CH₂-OH]₄.Si-[O-CH₂-CH(OH)-CH₂-OH]₄.12C₃H₈O.48H₂O, obtained by interaction of butylorthotitanate and ethylorthosilicate with glycerol in molar ratio of 1:1:20, respectively, at 100-120°C in vacuum while removing of formed mixture of ethanol and butanol, followed by addition of acidified water with pH 2.5-3.5 and conditioning at 85°C or lower for at least 1.5 hour. Also disclosed is pharmaceutical composition containing aforementioned compound as active ingredient and carrier in ratio (mass %) of active ingredient 0.01-10.00; and balance: carrier.

EFFECT: enhanced assortment of biologically active ointment sources of penetrative dermatic action.

2 cl, 7 ex

Similar patents RU2306317C2

Title	Year	Author	Number
AQUEOUS-GLYCEROL COMPLEX (2,3-DIHYDROXYPROPYL)-ORTHO-TITANATE HYDROCHLORIDE AND PHARMACEUTICAL GEL-CONTAINING COMPOSITION ON ITS BASIS	1993	Kipper Svetlana Nikolaevna	RU2042683C1
AQUEOUS-GLYCEROL COMPLEX OF (2,3-DIHYDROXYPROPYL)-ORTHO-TITANATE	1991	Kipper S.N. Golomolzin B.V. Shakhtmejster I.Ja.	RU2053234C1
GEL-CONTAINING PHARMACEUTICAL COMPOSITION FOR LOCAL AND EXTERNAL APPLICATION	2008	Chupakhin Oleg Nikolaevich Khonina Tat'Jana Grigor'Evna Larionov Leonid Petrovich Sorokin Pavel Vladimirovich Ivanenko Marija Vladimirovna Bojko Anton Aleksandrovich Kollerova Marija Stanislavovna Zobnina Galina Aleksandrovna Zabokritskij Nikolaj Aleksandrovich	RU2417102C2
EPHTIDERM PREPARATION METHOD	2003	Kipper S.N. Baranov D.N. Baranov S.N. Orlov A.N.	RU2247726C1
WATER-SOLUBLE ORGANOSILICON DERIVATIVES OF POLYOLS AND HYDROGELS BASED ON SAID DERIVATIVES	2008	Chupakhin Oleg Nikolaevich Khonina Tat'Jana Grigor'Evna Larionov Leonid Petrovich Shadrina Elena Vladimirovna Bojko Anton Aleksandrovich Zabokritskij Nikolaj Aleksandrovich Volkov Artem Aleksandrovich	RU2382046C1
METHOD OF PRODUCING ETHIDERM	2008	Baranov Denis Nikolaevich Kipper Svetlana Nikolaevna Shchapov Viktor Aleksandrovich Shchapova Lidija Filippovna	RU2400486C2
SILICON-TITANIUM-CONTAINING POLYOL DERIVATIVES AND HYDROGELS BASED THEREON	2011	Chupakhin Oleg Nikolaevich Ivanenko Marija Vladimirovna Khonina Tat'Jana Grigor'Evna Larionov Leonid Petrovich Svetozerov Andrej Vladimirovich	RU2458929C1
WATER-SOLUBLE ORGANOSILICON GLYCERIN DERIVATIVE EXHIBITING TRANSMUCOUS ACTIVITY, AND BASED PHARMACEUTICAL COMPOSITION	2009	Burda Viktor Dmitrievich Bojko Anton Aleksandrovich Volkov Artem Aleksandrovich Ivanenko Marija Vladimirovna Larionov Leonid Petrovich Khonina Tat'Jana Grigor'Evna Chupakhin Oleg Nikolaevich Shadrina Elena Vladimirovna	RU2415144C2
SILICON IRON (ZINC, BORON) CONTAINING GLYCEROHYDROGEL FOR TOPICAL USE, HAVING HEMOSTATIC AND ANTIMICROBIAL ACTIVITY (OPTIONS)	2022	Charushin Valerij Nikolaevich Kungurov Nikolaj Vasilevich Chupakhin Oleg Niklaevich Khonina Tatyana Grigorevna Evstigneeva Natalya Petrovna Kokhan Muza Mikhajlovna Zilberberg Natalya Vladimirovna Gerasimova Natalya Avenirovna Tishin Denis Sergeevich Shadrina Elena Vladimirovna Nikitina Elena Yurevna Permikin Vasilij Viktorovich Starikov Nikita Mikhajlovich Larionov Leonid Petrovich Osipenko Artur Vasilevich Dobrinskaya Mariya Nikolaevna Sementsova Elena Anatolevna Kotikova Anastasiya Yurevna Mandra Yuliya Vladimirovna Bulatova Mariya Alekseevna	RU2797966C1
TITANIUMORGANIC GLYCEROGELAND METHOD OF ITS PRODUCTION	2016	Shchapov Viktor Aleksandrovich	RU2635088C1

RU 2 306 317 C2

Authors

Zhernakov Vladimir Sergeevich

Dates

2007-09-20—Published

2005-03-01—Filed