PSEUDOPOLYMORPHOUS FORMS OF CARVEDIOL Russian patent published in 2007 - IPC C07D209/88 A61K31/403 A61P9/00 

FIELD: pharmaceuticals, in particular composition for treatment or prophylaxis of heart diseases.

SUBSTANCE: invention relates to pharmaceutically acceptable composition containing crystalline form IV of (±)-1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamine]-2-propanol hemihydrate (carvediol) having melt temperature of 94-96°C or pharmaceutically acceptable salts thereof and pharmaceutically acceptable carrier and/or adjuvant having no surfactant properties, which has melt temperature 120°C or lower and is selected from polyethylene glycol and/or isomalt; and/or nonionic surfactant such as polyoxyethylene and polyoxypropylene copolymer. Claimed composition is obtained by melting of crystalline form of (±)-1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamine]-2-propanol (carvediol) having melt temperature of 123-126°C or 114-115°C or pharmaceutically acceptable salts thereof in abovementioned adjuvant and/or nonionic surfactant followed by fast cooling and addition of pharmaceutically acceptable carrier.

EFFECT: new pharmaceutical composition for treatment or prophylaxis of heart diseases.

15 cl, 7 dwg, 14 ex