FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to medicine. The method for production of pharmaceutical microparticulates with improved crystalline drug substance condition, comprising normal melting and freezing method modification by adding volatile ingredients or to melted mix, or to the process medium, or to the both.
EFFECT: production of pharmaceutical multiparticulates that contain drug substance with reasonably low levels of the substance converted into different crystalline form or amorphous state.
17 cl, 3 ex, 2 tbl
