THE DECREASE OF TISSUE VOLUME Russian patent published in 2007 - IPC A61K38/36 A61K38/17 A61K31/03 A61M37/00 A61B1/267 

FIELD: medicine, pulmonology.

SUBSTANCE: the present innovation should be applied in case of pulmonary diseases that require decreased volume of affected pulmonary tissue or its sealing in case of spontaneous pneumothorax. So, through a bronchoscope applied towards a target part it is necessary to introduce certain material along a catheter. The quantity of the origin of this material should be sufficient for stimulating the adhesion between one collapse-affected sector of a pulmonary target part and another, and fibrosis of a pulmonary target part or around a pulmonary target part in which this collapse took place. The present material based upon pharmaceutical compositions contains a polypeptide growth factor, a component of extracellular matrix, a vasoactive substance and a proapoptotic agent. Moreover, the compositions additionally include fibrinogen or fibrin monomer, or fibrinogen's activator. The innovation enables to achieve directed stimulation of the adhesion of a target part, fibrosis of a target part itself or around the sector in which collapse took place.

EFFECT: higher efficiency.

70 cl, 14 dwg, 9 ex, 4 tbl